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材料与化工

何福生

姓名:何福生,性别:男                    

学科专业:材料与化工

学历及学位:研究生,博士

职称:讲师

联系方式:Email: hefs@tzc.edu.cn

 

学习经历:

2012年毕业于江西师范大学,化学专业,获理学学士学位

2017年毕业于华东理工大学,药学专业,获医学博士学位

工作经历:

20177月至201712月,上海合全药物研发有限公司,任高级研究员

20181月至201912月,浙江大学,博士后

20192月至今,台州学院

研究方向:
    自由基化学;不对称催化;药物化学

主要科研项目:

1)国家自然科学基金项目,《硫(VI)中心手性的催化不对称构建及应用研究》(22101199),2022.1-2024.1230万,主持。

  2)浙江省自然科学基金项目,《基于张力释放策略构建双环[1.1.1]戊烷衍生物的研究》(LQ21B020002),2021.1-2023.1210万,主持。

近期代表性论文及成果:

1He, Fu-Sheng*; Bao, Ping; Tang, Zhimei; Yu, Feiyan; Deng, Wei-Ping; Wu, Jie*. Photoredox-Catalyzed α-Sulfonylation of Ketones from Sulfur Dioxide and Thianthrenium Salts. Org. Lett. 2022, 24, 2955-2960.

2He, Fu-Sheng*; Su, Lingjing; Yu, Feiyan; Tang, Zhimei; Wu, Jie*. Construction of sulfonated spiro[5,5]trienones from sulfur dioxide via iron-catalyzed dearomative spirocyclization of biaryls. Org. Chem. Front. 2022, 9, 1937-1942.

3He, Fu-Sheng*; Yao, Yanfang; Tang, Zhimei; Qiu, Yanjie; Xie, Wenlin; Wu, Jie*. Synthesis of β-cyanoalkylsulfonylated vinyl selenides through a four-component reaction. Chem. Commun. 2021, 57, 12603-12606.

4He, Fu-Sheng*; Bao, Ping; Yu, Feiyan; Zeng, Ling-Hui; Deng, Wei-Ping; Wu, Jie*. Copper-Catalyzed Regioselective 1,4-Selenosulfonylation of 1,3-Enynes to Access Cyanoalkylsulfonylated Allenes. Org. Lett. 2021, 23, 7472-7476.

5He, Fu-Sheng*; Yao, Yanfang; Tang, Zhimei; Xie, Wenlin; Wu, Jie*. Copper-catalyzed regio- and chemoselective selenosulfonylation of 1,6-enynes from sulfur dioxide. Org. Chem. Front. 2021, 8, 6119-6124.

6Bao, P.; Yu, Feiyan; He, Fu-Sheng*; Tang, Zhimei; Deng, Wei-Ping; Wu, Jie*. Visible-light-induced remote C(sp3)-H sulfonylvinylation: assembly of cyanoalkylated vinyl sulfones. Org. Chem. Front. 2021, 8, 4820-4825.

7He, Fu-Sheng*; Zhang, Man; Zhang, Mengke; Luo, Xiangxiang; Wu, Jie*. Iminyl radical initiated sulfonylation of alkenes with rongalite under photoredox conditions. Org. Chem. Front. 2021, 8, 3746-3751.

8Yao, Yanfang; Yin, Ziqing; He, Fu-Sheng*; Qin, Xuwei; Xie, Wenlin*; Wu, Jie*. Photoinduced intramolecular carbosulfonylation of alkynes: access to sulfone-containing dibenzazepines from sulfur dioxide. Chem. Commun. 2021, 57, 2883-2886.

9Cen, Xufen; Chen, Yanying; Xu, Xiaoyan; Wu, Ronghai; He, Fusheng; Zhao, Qingwei; Sun, Qiming; Yi, Cong; Wu, Jie*; Najafov, Ayaz;* Xia, Hongguang* Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model. Nat. Commun. 2020, 11, 5731.

10He, Fu-Sheng; Yao, Yanfang; Xie, Wenlin; Wu, Jie. Photoredox-catalyzed sulfonylation of difluoroenoxysilanes with the insertion of sulfur dioxide. Chem. Commun. 2020, 56, 9649-9472.

10Huang, Jiapian; Ding, Feng; Rojsitthisak, Pornchai; He, Fu-Sheng*; Wu, Jie*. Recent advances in nitro-involved radical reactions. Org. Chem. Front. 2020, 7, 2873-2898.

11Gong, Xinxing; Yang, Min; Liu, Jin-Biao; He, Fu-Sheng*; Fan, Xiaona*; Wu, Jie*. A metal-free route to alkynyl sulfones under photoinduced conditions with the insertion of sulfur dioxide. Green. Chem. 2020, 22, 1906-1910.

12Zhang, Jun; Yang, Min; Liu, Jin-Biao; He, Fu-Sheng*; Wu, Jie*. A copper-catalyzed insertion of sulfur dioxide via radical coupling. Chem. Commun. 2020, 56, 3225-3228.

13He, Fu-Sheng; Ye, Shengqing; Wu, Jie*. Recent Advances in Pyridinium Salts as Radical Reservoirs in Organic Synthesis. ACS Catal. 2019, 9, 8943-8960.

14He, Fu-Sheng; Jin, Jing-Hai; Yang, Zhong-Tao; Yu, Xingxin; Fossey, John S.; Deng, Wei-Ping. Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides. ACS Catal. 2016, 6, 652-656. 

个人荣誉及获奖:

入选台州学院青年英才培养人选(2020)。

获台州市自然科学学术奖三等奖(2020)。