国家自然科学基金青年项目《仿生智能纳米孔道的构筑及其在肝癌相关miRNA逻辑检测中的应用》，(21904093), 2020.01-2022.12, 25万元，主持。
（2）浙江省公益技术应用研究项目，《纳米孔单细胞传感器的研发及其在端粒酶检测中的应用》（LGF22B050001），2022.1-2024.1,10万，主持。
（3）浙江省自然科学基金青年项目，《利用纳米孔技术和杂交链式反应实现对DNA和miRNA的超灵敏检测》（LQ17B050001），2017.1-2019.12，6万，主持。
（4）中国博士后基金面上资助二等，《纳米孔单细胞传感器的制备及其在肿瘤标志物检测中的应用》（2022M722313），2023.01-2024.12，8万，主持。
（5）中国博士后基金面上资助二等，《基于级联反应的纳米孔传感器在肿瘤标志物检测中的应用》（2018M642403），2019.01-2020.12，5万，主持。
近期代表性论文及成果：
（1）Siqi Zhang, Huahao Shao, Wei Shi, Kai-Bin Li, Nan You, De-Man Han,* and Jinggang Mo*. Asymmetric Nanopore Sensor for Logic Detection of Dam and M.SssI Methyltransferases in Combination of DNA Walker and Autocatalytic Hybridization Reaction, Analytical Chemistry, 2024, 96, 16415−16424
（2）Siqi Zhang, Wei Shi, Kai-Bin Li, De-Man Han*, Jing-Juan Xu. Ultrasensitive and Label-Free Detection of Multiple DNA Methyltransferases by Asymmetric Nanopore Biosensor, Analytical Chemistry, 2022, 94: 4407-4416
（3）Siqi Zhang, Jiaxi Cheng, Wei Shi, Kai-Bin Li, De-Man Han*, Jing-Juan Xu. Fabrication of a Biomimetic Nanochannel Logic Platform and Its Applications in the Intelligent Detection of miRNA Related to Liver Cancer. Analytical Chemistry. 2020, 92, 5952-5959
（4）Siqi Zhang, Huahao Shao, Kai-Bin Li,* Wei Shi, De-Man Han.* Nanofluidic sensing platform for PNK assay using nonlinear hybridization chain reaction and its application in DNA logic circuit. Biosensors and Bioelectronics, 2023, 240, 115632
（5）Siqi Zhang, Huahao Shao, Kai-Bin Li, Wei Shi, Yichao Wang,* De-Man Han,* Ultrasensitive fluorescence detection of multiple DNA methyltransferases based on DNA walkers and hyperbranched rolling circle amplification, Analytica Chimica Acta, 2023, 1252, 341057
（6）Siqi Zhang, Kai-Bin Li, Yuanjiang Pan*, De-Man Han*. Ultrasensitive detection of ochratoxin A based on biomimetic nanochannel and catalytic hairpin assembly signal amplification. Talanta, 2020, 220, 121420
（7）Siqi Zhang, Kai-Bin Li, Wei Shi, Jie Zhang, De-Man Han*, Jing-Juan Xu. Resettable and enzyme-free molecular logic devices for the intelligent amplification detection of multiple miRNAs via catalyzed hairpin assembly. Nanoscale, 2019, 11, 5048-5057
（8）Siqi Zhang, Wei Shi, Kai-Bin Li, Fengzao Chen, Jie Su, De-Man Han*. Graphene oxide/silver nanoclusters based logic devices and their application to multiplexed analysis of miRNA. Sensors and Actuators B: Chemical, 2018, 273, 408-417
（9）Siqi Zhang, Kun Wang, Kai-Bin Li, Fengzao Chen, Wei Shi, Wen-Ping Jia, Jie Zhang, De-Man Han*. A label-free and universal platform for the construction of an odd/even detector for decimal numbers based on graphene oxide and DNA-stabilized silver nanoclusters. Nanoscale, 2017, 9, 11912-11919
（10）Siqi Zhang*, Kun Wang, Kai-Bin Li, Wei Shi, Wen-Ping Jia, Xiaoying Chen, Ting Sun, De-Man Han*. A DNA-Stabilized Silver Nanoclusters/Graphene Oxide-Based Platform for the Sensitive Detection of DNA through Hybridization Chain Reaction. Biosensors and Bioelectronics, 2017, 91, 374–379
个人荣誉及获奖：
