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临床医学

何泽宝

姓名:何泽宝,性别:

学科专业:内科学

学历及学位:本科学历,医学硕士学位

职称:主任医师,副教授

职务:台州市公共卫生医学中心副主任(主持工作),恩泽医院感染科主任

联系方式:Email:hezb@enzemed.com

学习经历:

1992.7毕业于温州医学院 获学士学位

2006.7毕业于浙江大学医学院 获医学硕士学位

1999-2000复旦大学附属华山医院感染科进修

工作经历:

19928月至20099月 浙江省台州医院感染科 副主任 主任医师 温州医科大学硕导

200910月至20139月复旦大学附属上海市第五人民医院感染科 常务副主任(主持工作)主任医师

201310至今 台州市恩泽医疗中心(集团)恩泽医院感染科主任 主任医师 台州市公共卫生医学中心副主任(主持工作)温州医科大学硕导

社会主要兼职:

浙江省防痨协会常务理事、浙江省医学会结核分会常委、台州市医学会结核分会主委、台州市医学会肝病分会副主委、台州市结核临床质控中心副主任

研究方向:
   肝纤维化、肝癌防治,分枝杆菌感染防治

 

主要科研项目:

主持浙江省自然科学基金项目1项、主持台州市科技计划项目3项

近期代表性论文及成果:

1: Zhao HH, Chen CL, Chen FF, Zhang LL, Li MM, He ZB. Molecular mechanism of

ALKBH5-mediated m6A demethylation regulating lipopolysaccharide-induced

epithelial-mesenchymal transition in sepsis-induced acute kidney injury.

Kaohsiung J Med Sci. 2024 Sep 17. doi: 10.1002/kjm2.12892. Epub ahead of print.

PMID: 39287046.

2: Wang G, He Z, Wu F, Ge Z, Zhu J, Chen Z. IgG response to spike protein of

SARS-CoV-2 in healthy individuals and potential of intravenous IgG as treatment

for COVID-19. Virol J. 2022 Nov 13;19(1):186. doi: 10.1186/s12985-022-01921-z.

PMID: 36372879; PMCID: PMC9655819.

3: Rui F, Yang H, Guo Z, Ge Z, Hu X, Zhang L, Xue Q, Chen H, Xu Y, Tan M, Qin C,

He Z, Li J. Derivation and validation of prognostic models for predicting

survival outcomes in Acute-on-chronic liver failure patients. J Viral Hepat.

2021 Dec;28(12):1719-1728. doi: 10.1111/jvh.13611. Epub 2021 Oct 15. PMID:

34496100.

4: Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, Quan S, Zhang F, Sun R, Qian L, Ge

W, Liu W, Liang S, Chen H, Zhang Y, Li J, Xu J, He Z, Chen B, Wang J, Yan H,

Zheng Y, Wang D, Zhu J, Kong Z, Kang Z, Liang X, Ding X, Ruan G, Xiang N, Cai X,

Gao H, Li L, Li S, Xiao Q, Lu T, Zhu Y, Liu H, Chen H, Guo T. Proteomic and

Metabolomic Characterization of COVID-19 Patient Sera. Cell. 2020 Jul

9;182(1):59-72.e15. doi: 10.1016/j.cell.2020.05.032. Epub 2020 May 28. PMID:

32492406; PMCID: PMC7254001.

5: Hong LX, Lin A, He ZB, Zhao HH, Zhang JG, Zhang C, Ying LJ, Ge ZM, Zhang X,

Han QY, Chen QY, Ye YH, Zhu JS, Chen HX, Yan WH. Mask wearing in pre-symptomatic

patients prevents SARS-CoV-2 transmission: An epidemiological analysis. Travel

Med Infect Dis. 2020 Jul-Aug;36:101803. doi: 10.1016/j.tmaid.2020.101803. Epub

2020 Jun 24. PMID: 32592903; PMCID: PMC7311905.

6: He Z, Zhu J, Mo J, Zhao H, Chen Q. HBV DNA integrates into upregulated

ZBTB20 in patients with hepatocellular carcinoma. Mol Med Rep. 2020

Jul;22(1):380-386. doi: 10.3892/mmr.2020.11074. Epub 2020 Apr 16. PMID:

32319639; PMCID: PMC7248478.

7: He Z, Li J. Comment on Cai et al. Obesity and COVID-19 Severity in a

Designated Hospital in Shenzhen, China. Diabetes Care 2020;43:1392-1398.

Diabetes Care. 2020 Oct;43(10):e160-e161. doi: 10.2337/dc20-1195. PMID:

32958624; PMCID: PMC7510038.

8: Yu Z, Lu R, Gan M, Tu X, He Z. Mycobacterial identification on homogenised

biopsy facilitates the early diagnosis and treatment of laryngeal tuberculosis.

Open Med (Wars). 2020 Jun 5;15(1):508-512. doi: 10.1515/med-2020-0171. PMID:

33336005; PMCID: PMC7712452.

9: Lin A, He ZB, Zhang S, Zhang JG, Zhang X, Yan WH. Early Risk Factors for the

Duration of Severe Acute Respiratory Syndrome Coronavirus 2 Viral Positivity in

Patients With Coronavirus Disease 2019. Clin Infect Dis. 2020 Nov

19;71(16):2061-2065. doi: 10.1093/cid/ciaa490. PMID: 32337591; PMCID:

PMC7197613.

10: Yu ZJ, Zhang LL, Huang TT, Zhu JS, He ZB. Comparison of mycophenolate

mofetil with standard treatment for autoimmune hepatitis: a meta-analysis. Eur J

Gastroenterol Hepatol. 2019 Jul;31(7):873-877. doi:

10.1097/MEG.0000000000001367. PMID: 31150366.

11: Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X,

Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou

L, Li X, Zou S, Zhang Y, Li X, Yang L, Guo J, Dong J, Li Q, Dong L, Zhu Y, Bai

T, Wang S, Hao P, Yang W, Zhang Y, Han J, Yu H, Li D, Gao GF, Wu G, Wang Y, Yuan

Z, Shu Y. Human infection with a novel avian-origin influenza A (H7N9) virus. N

Engl J Med. 2013 May 16;368(20):1888-97. doi: 10.1056/NEJMoa1304459. Epub 2013

Apr 11. PMID: 23577628.

12: Jie Z, Xie J, He Z, Song Y, Hu Y, Li F, Shen Y, Shi J, He Y, Huang Q, Gu Y,

Bai C. Family outbreak of severe pneumonia induced by H7N9 infection. Am J

Respir Crit Care Med. 2013 Jul 1;188(1):114-5. doi: 10.1164/rccm.201304-0797LE.

PMID: 23815728.

13: Shi J, Xie J, He Z, Hu Y, He Y, Huang Q, Leng B, He W, Sheng Y, Li F, Song

Y, Bai C, Gu Y, Jie Z. A detailed epidemiological and clinical description of 6

human cases of avian-origin influenza A (H7N9) virus infection in Shanghai. PLoS

One. 2013 Oct 15;8(10):e77651. doi: 10.1371/journal.pone.0077651. PMID:

24143251; PMCID: PMC3797049.

个人荣誉及获奖:

2020.7获中国农工民主党浙江省委员会授予抗疫一线优秀党员荣誉称号

2020.9.4获浙江省医师协会、浙江省医学会联合授予的浙江省抗疫突出贡献感染科医师荣誉称号

2020.12获中共台州市委、台州市人民政府颁发的台州市抗击新冠肺炎疫情先进个人荣誉称号

2020.12获中国农工民主党中央委员会颁发的农工党抗击新冠肺炎疫情先进个人荣誉称号