姓名：姜大伟，性别：男                   

学科专业：生物材料

学历及学位：研究生，博士

职称：副研究员

职务：无

联系方式：Email:18321314385@163.com

学习经历：

2013年毕业于江苏科技大学，获物理学学士学位

2020年毕业于华东理工大学，获工学博士学位（硕博）

工作经历：

2020年6月至2022年7月，国科大温州研究院 博士后（第一站）

2022年10月至2024年12月，温州医科大学药学院 博士后 （第二站）

2025年1月至今，温岭市第一人民医院，基础与临床研究中心，岗位研究员

社会主要兼职：

无

研究方向：
    主要从事生物医用高分子与纳米药物递送系统研究，聚焦神经损伤、神经退行性疾病、抗肿瘤、以及抗菌治疗等生物学和医学科学问题，开发可注射水凝胶、功能化脂质体、聚合物纳米粒等载体，实现多药异步 / 酶响应可控释放，探究铁死亡、线粒体‑溶酶体稳态、AMPK等作用通路，致力于推动相关疾病的治疗策略转化研究。

主要科研项目：

主持和参与国家自然科学基金2项，浙江省自然科学基金项目1项、中国博士后项目1项、台州市科技计划项目1项。

近期代表性论文及成果：

（1）Dawei Jiang, Zhiyang Huang, Peng Dai, Yibo Ying, Ziyi Li, Shaoxia Ning, Caiyan Li, Na Dong, Jiali Lv, Yuchao Zhang, Min Liu, Kaihang Yu, Zhenwen Xie, Chang Xue, Xuehai Chen, Fenzan Wu, Xiaojie Wei, Xiaokun Li, Zhouguang Wang，A proactive cholinergic-like acidic fibroblast growth factor delivery system for efficient protein enrichment and native drug release in the central nervous system to promote repair of injured spinal cord，Biomaterials，2026, 326, 123636.(第一作者，IF=13.6，中科院一区)

（2）Yibo Ying, Xiong Cai, Peng Dai, Yuchao Zhang, Jiali Lv, Zhiyang Huang, Xuehai Chen, Yusi Hu, Yunjie Shi, Xiaokun Li*, Dawei Jiang*, Zhouguang Wang*, Neurological Emergency Treatment Strategy: A Neuron-Targeted Regulation System for Reactive Oxygen Species Metabolism through Ferroptosis Modulation, ACS Nano, 2025, 19, 8753–8772. (共通讯，IF=15.8，中科院一区)

（3）Junpeng Xu#, Peng Dai#, Chen Zhang#, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih-Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li*, Shan-hui Hsu*, Dawei Jiang*, Zhouguang Wang*, Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease, Advanced Science, 2025, 12, 2412020. (共通讯，IF=14.3，中科院一区)

（4）Dawei Jiang#, Chao Chen#, Peng Dai#, Caiyan Li, Zhiyi Feng, Na Dong, Fenzan Wu, Junpeng Xu, Ping Wu, Liuxi Chu, Shengcun Li, Xiaokun Li*, Youjun Yang*, Weian Zhang*, Zhouguang Wang*, Deep near infrared light excited stable synergistic photodynamic and photothermal therapies based on P-IR890 nano-photosensitizer constructed via a non-cyanine dye, Asian Journal of Pharmaceutical Sciences, 2024, 19, 100955. (一作，IF=10.7，中科院一区)

（5）Dawei Jiang#, Luqi Pan#, Xiao Yang, Zhixiao Ji, Cheng Zheng, Zhizhen Meng, Bin Liang, Weian Zhang*, Jinfei Chen*, Changcan Shi*, Photo-controllable burst generation of peroxynitrite based on synergistic interactions of polymeric nitric oxide donors and IR780 for enhancing broad-spectrum antibacterial therapy, Acta Biomaterialia, 2023, 159, 259-174. （一作，IF=9.4，中科院一区）

（6）Dawei Jiang#, Lei Cheng#, Yudong Xue, Chao Chen, Chaochao Wang, Guoliang Yang, An Xu*, Youjun Yang*, Yun Gao, Weian Zhang*, Modulation of the Lifespan of C.elegans by Controlled Release of Nitric Oxide, Chemical Science, 2020, 11, 8785-8792. (一作，IF=7.6，中科院一区)

（7）Dawei Jiang#, Chao Chen#, Yudong Xue, Hongliang Cao, Chaochao Wang, Yun Gao, Ping Wang, Weianzhang*, NIR-triggered “OFF/ON” Photodynamic Therapy through a Upper Critical Solution Temperature Block Copolymer, ACS Applied Materials & Interfaces, 2019, 11 (40), 37121-37129. (一作，IF=8.5，中科院二区)

（8）Dawei Jiang, Tao Yue, Guichen Wang, Chaochao Wang, Chao Chen, Hongliang Cao*, YunGao*, Peroxynitrite(ONOO─) Generation from HA-TPP@NORM Nanoparticles based on Synergistic Interaction between Nitric Oxide and Photodynamic Therapies for Elevating Anticancer Efficiency, New Journal of Chemistry, 2020, 44, 162-170. (一作，IF=2.7, 中科院三区)

（9）Bin Liang#; Dawei Jiang#; Luqi Pan#; Fang Xiong; Shuya Feng; Shenghao Wu; Haige Ye; Zhijie Yu; Changcan Shi*, Shenmeng Gao*, Lipase-trigged drug release from BCL2 inhibitor ABT-199-loaded nanoparticles to elevate anti-leukemic activity through enhancing drug aggregation on the mitochondrial membrane, Acta Biomaterialia, 2022, 145, 246-259. (共同一作，IF=9.4，中科院一区)

（10）Xiang Zhang#, Dawei Jiang#, Guoliang Yang, Yucheng Zhu, Jia Tian, Hongliang Cao, Yun Gao*, Weian Zhang*, A Single-wavelength NIR-triggered Polymer for in situ Generation of Peroxynitrite (ONOO－) to Enhance Phototherapeutic Efficacy, Chinese Journal of Polymer Science, 2021, 39,692-701. (共同一作，IF = 4.1，中科院二区)

（11）Lingling Pan#, Dawei Jiang#, Luqi Pan, Zhizhen Meng, Yangyang Zhuang, Cheng Zheng, Changcan Shi*, Jie Chen*, Jingye Pan*, ICAM-1-targeted and antibacterial peptide modified polymeric nanoparticles for specific combating sepsis, Materials and Design, 2022, 222, 111007. (共同一作，IF=7.6, 中科院二区).

个人荣誉及获奖：

无